Woman, 40, denied life-extending cancer drug announces her death

Woman, 40, denied life-extending cancer drug announces her death

Woman, 40, denied life-extending cancer drug announces her death

Woman, 40, denied life-extending cancer drug announces her death

The drug could’ve given Swansea mum Rachel Davies an extra six months

A woman who was denied a life-extending cancer drug has announced her own death in a heartbreaking statement urging others to ‘live your life and live it well’.

Rachel Davies was diagnosed with secondary breast cancer which had spread to her bones, back, neck and pelvis.

The 40-year-old had prepared a post to be posthumously shared on social media and it went live on Thursday morning, confirming she is ‘no longer here’.

Davies had been a campaigner for the drug Enhertu which can give patients with a specific type of incurable breast cancer an average of an extra six months to live. It is not currently available on the NHS.

The mum from Swansea had previously told BBC Wales News she thought there would be a high chance of it working for her.

Rachel had campaigned for the drug (Facebook)

Rachel had campaigned for the drug (Facebook)

“I just want the chance, the chance to be able to live,” she said when receiving her final chemotherapy treatment through the NHS. “That’s why I’m doing this, for my son and my family, not just for me.”

Davies’ oncologist from Swansea Bay health board had applied for specialist funding for the drug but it was refused.

At the time, it said it ‘carefully considers all requests for the funding of treatments that fall outside normal treatment protocols’ and takes NICE (the health assessment body) recommendations into account.

NICE decided against recommending the drug in July, citing it as not cost-effective and instead called on pharmaceutical companies to offer a fairer price.

Announcing her death on Facebook, Davies wrote: “If you’re reading this, then it means I’m no longer here, I can’t say to a better place as that is impossible!

“What a life I’ve had, and surprisingly, since cancer entered my life. When I look through my photos, I’ve done and seen so much since cancer, and probably some of my best memories are from this period. In so many ways, I have to thank it for learning how to live fully.

“What I wish is that everyone can experience the same but without needing cancer. Get out there, experience life fully, and wear that dress!!!

She prepared a Facebook post before she died. (Facebook)

She prepared a Facebook post before she died. (Facebook)

“I’m so sad to leave my family and friends, I wish I never had to go. I’m so grateful to have had Charlie young so that I’ve watched him grow into the man he is today, I’m unbelievably proud of him. I am thankful I had the opportunity to have Kacey and Jacob in my life.

“Lastly, I was blessed to meet the love of my life, my husband, and my best friend. I have no regrets.

“I have had a wonderful life.

“So to all of you, don’t be sad I’ve gone. Live your life and live it well. Love, Rachel x.”

Having criticised the decision to not make the life-extending drug available, charity Breast Cancer Now told the BBC: “Rachel was a tireless campaigner for the drug Enhertu, and an incredible advocate for people living with secondary breast cancer.

“We will miss you Rachel. Thank you for being such an important part of our campaigning work.”

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Emma Watson helped launch a sєχual harassment hotline for women in the UK at work

Emma Watson helped launch a sєχual harassment hotline for women in the UK at work

Emma Watson Helps Launch Workplace Sexual Harassment Hotline

Emma Watson is teaming up with Time’s Up and the organization, Rights of Women, to help launch a legal advice hotline for women in the UK who have experienced sexual harassment in the workplace.

The cost-free service is currently available for women in England and Wales, and according to the British actress, it’s the only one of its kind.

“It’s completely staggering to think that this is the only service of its type given that research has found that as many as one in two women experience sexual harassment in the workplace,” Watson, 29, said in an official statement. “It finally feels like people are realizing the scale of the problem.”

NEW YORK, NY - MAY 02: Emma Watson attends the

NEW YORK, NY – MAY 02: Emma Watson attends the “Manus x Machina: Fashion In An Age Of Technology” Costume Institute Gala at Metropolitan Museum of Art on May 2, 2016 in New York City. (Photo by Dimitrios Kambouris/Getty Images) (2016 Getty Images)

According to the Rights of Women website, the hotline was funded “by the public,” and will help women “get specialist legal advice on what behavior constitutes sexual harassment, how to bring a grievance against their employer, how to make a claim in the Employment Tribunal, settlement agreements and non-disclosure agreements (NDAs) and other related legal problems faced by women experiencing sexual harassment in the workplace.”

Watson went on to discuss the importance of the hotline in her statement.

“Understanding what your rights are, how you can assert them, and the choices you have if you’ve experienced harassment, is such a vital part of creating safe workplaces for everyone, and this advice line is such a huge development in ensuring that all women are supported, wherever we work,” the former “Harry Potter” star said.

Watson has been a strong supporter of the #MeToo movement, and in February 2018, she notably donated about $1.4 million to the Justice and Equality Fund, a UK-based organization which aims to prevent sexual harassment, assault and discrimination.

In 2016, she also launched a feminist Goodreads book club, titled “Our Shared Shelf.” The club, which is still ongoing, recommends one book every two months, with each book revolving around themes of gender equality.

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Woman who went missing while on vacation speaks out as she's found safe after father died during search for her

Woman who went missing while on vacation speaks out as she’s found safe after father died during search for her

Woman who went missing while on vacation speaks out as she's found safe after father died during search for her

Hannah Kobayashi has been missing since last month

A woman who went missing while on vacation has finally got in touch with her family after vanishing a month ago.

Hannah Kobayashi had been traveling from her home in Maui, Hawaii, to get a connecting flight to New York via Los Angeles last month. However, she never actually boarded the flight to New York.

Here’s everything we know so far, including what she has said to her family this week.

Nov 8: Kobayashi misses her flight and a search begins

Kobayashi’s family say they received texts claiming someone was trying to steal her identity and having grew concerned, they reported her missing.

A widespread search was sparked for the aspiring photographer, with Kobayashi’s father Ryan Kobayashi flying from Maui to LA and multiple alleged sightings reported.

Police previously gave a rundown of Kobayashi’s disappearance, though that caused quite the stir with the family.

And during their investigation, police dismissed speculation Kobayashi was involved in any type of criminal activity.

Nov 24: Ryan Kobayashi dies

Kobayashi’s father Ryan was tragically found dead at 4.00am in a car park near the airport in what is believed to be a suicide.

Just days before his death the 58-year-old was seen handing out missing person flyers.

A family statement at the time said: “The Kobayashi family endured a devastating tragedy today. After tirelessly searching throughout Los Angeles for 13 days, Hannah’s father, Ryan Kobayashi, tragically took his own life. This loss has compounded the family’s suffering immeasurably.

“What the family needs most in this difficult time is for all communities to rally around them with support, compassion, and prayers. Please be considerate with your comments and posts. The trauma they are enduring is profound, and they now face the additional burden of grieving the loss of their family’s pillar and navigating next steps.”

Ryan Kobayashi spoke candidly about his daughter before tragically dying days later (KCAL News)

Ryan Kobayashi spoke candidly about his daughter before tragically dying days later (KCAL News)

Nov 26: Police have major breakthrough

LAPD Chief Jim McDonnell announced during a Los Angeles Board of Police Commissioners meeting that officials believed Kobayashi missed her flight on purpose and had gone missing voluntarily.

The family disputed the claims made by authorities.

Hannah Kobayashi had been missing since last month (ABC10)

Hannah Kobayashi had been missing since last month (ABC10)

Dec 2: The case is re-classified

A few days later, the case is officially re-classified, with Hannah now considered a voluntary missing person after being spotted crossing the border into Mexico.

Dec 11: Kobayashi found ‘safe’

An update was finally provided on the case as Kobayashi was found ‘safe and well’ in Mexico.

“We are incredibly relieved and grateful Hannah has been found safe,” a family statement shared with the Mail Online stated.

Kobayashi is currently in Mexico (Facebook)

Kobayashi is currently in Mexico (Facebook)

What has Hannah Kobayashi said since her disappearance?

Kobayashi’s sister Sydni said she’d been speaking to her sister over the phone, where she detailed her plans for the future.

In a statement penned on social media, Sydni wrote: “When my father suddenly passed away, I added his funeral expenses and arrangements to the campaign as next of kin.

“At this time, my mother and I have not physically seen Hannah. We do not have actual proof of where she is, other than that she is somewhere in Mexico. We have only spoken to her over the phone, and she was allegedly found safe with Larie, but at this time, she does not wish to return to us.”

Hannah Kobayashi doesn't want to return home (ABC7)

Hannah Kobayashi doesn’t want to return home (ABC7)

The statement continued: “As you can imagine, we are all extremely relieved and glad that my sister is alive and seemingly okay, but we also have mixed and overwhelming feelings of exhaustion, devastation, and betrayal. We are kindly asking the public to respect our privacy and offer us grace for a moment as we are still grieving. There is still so much unknown, and so much that still needs to be navigated.

“In due time, the truth will surface, and we will all get the answers we truly deserve. I stand by the choices I’ve made for my family, and we know where our hearts lie in this. I would never wish this type of experience upon anyone, especially not back-to-back.”

Sydni concluded the message by thanking those who have supported the family through the GoFundMe and through general well wishes.

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Elon Musk 21 Years Ago: Revealing SpaceX Plans Shocked Everyone

Elon Musk 21 Years Ago: Revealing SpaceX Plans Shocked Everyone

21-year-old footage footage of Elon Musk outlining his plans for SpaceX leaves people mind-blown

The video was taken of the tech mogul at Stanford University in 2003

A 21-year-old video of Elon Musk has emerged online where the tech mogul shared his plans for SpaceX.

Musk founded SpaceX in 2002, and fast forward to today, it has become a leader in the space industry.

It’s said to have a value of around $180 million, while Musk himself has a net worth of almost $355 billion – making him the richest man in the world.

A year after he launched SpaceX, the businessman gave a speech at Stanford University where he outlined his strategic plans for his space company.

While a lot has changed in 20 years, Musk’s plans for SpaceX have not.

In the video that’s been doing the rounds on Twitter (X) of late – which is now owned by the multibillionaire – a youthful-looking Musk says: “Our approach is really to make this a solid, sound business.

“I predicated the strategic plan on a known market, something that we know for a fact exists, which is the need to put small to medium-sized satellites into orbit.”

Elon Musk founded SpaceX in 2002 (Paul Harris/Getty Images)

He continued: “That’s what we’re going after initially. And then, with that as a revenue base, we will move into the human transportation market.

“The long-term aims of the company are definitely human transportation.

“I think the smart strategy is to first go for cargo delivery, essentially satellite delivery.

“And our eventual upgrade path is to build the successor to Saturn V, build a super-heavy lift vehicle that could be used for setting up a moon base or doing a Mars mission.

“That would be the holy grail objective.”

And Musk stood to his plans, recently achieving one of his goals of sending people to space.

Elon Musk Now Owns Less Than Half Of SpaceX's Shares Reveal Filings : r/ spacexELON CLIPS

Here’s Elon Musk in 2003 outlining the strategic plan SpaceX has been following until today. “Our approach is really to make this a solid, sound business. I predicated the strategic plan on a known market, something that we know for a fact exists, which is the need to put small to medium-sized satellites into orbit. That’s what we’re going after initially. And then, with that as a revenue base, we will move into the human transportation market. The long-term aims of the company are definitely human transportation. I think the smart strategy is to first go for cargo delivery, essentially satellite delivery. And our eventual upgrade path is to build the successor to Saturn V, build a super-heavy lift vehicle that could be used for setting up a moon base or doing a Mars mission. That would be the holy grail objective.” Stanford University, October 8, 2003

Here’s Elon Musk in 2003 outlining the strategic plan SpaceX has been following until today. “Our approach is really to make this a solid, sound business. I predicated the strategic plan on a known market, something that we know for a fact exists, which is the need to put small…

On September 10 of this year, SpaceX’s Falcon 9 rocket was launched into space for a five-day flight.

Billionaire Jared Isaacman went on to become the first person to take part in a private spacewalk, which was documented in ‘gorgeous’ footage.

Isaacman and the rest of the team on board Falcon 9 were sent up to space to test a new series of slimmer spacesuits, all while marking ‘the first time four humans [have been] simultaneously exposed to the vacuum of space’ coming out of a capsule with no safety airlock as well.

Adding to the momentous achievement, all four people were civilians rather than trained astronauts for NASA or the military.

Alongside billionaire Isaacman were retired Air Force Lt Col Scott ‘Kidd’ Poteet, and SpaceX engineers Anna Menon and Sarah Gillis.

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Artist Reimagines Disney Characters with Contemporary Beauty Trends

Artist Reimagines Disney Characters with Contemporary Beauty Trends

Artist Reimagines Disney Characters with Contemporary Beauty Trends

Yudie, the talented artist behind the viral TikTok account @vanotyarts, has taken the internet by storm with her unique redesigns of Disney characters inspired by modern beauty standards. Her creative “glow-ups” have captivated millions, blending iconic characters with contemporary aesthetics. One of her most popular videos, a stunning reimagining of Rapunzel, has amassed 17 million views, sparking discussions about how beauty perceptions have changed over time.

1. Jasmine (Aladdin)

Jasmine has been given a dramatic makeover. The updated version features a sultry smokey eye and thicker, more defined lashes, adding depth and intensity to her already captivating appearance.

2. Ariel (The Little Mermaid)

Ariel’s pink dress in The Little Mermaid was inspired by 1830s design trends, particularly the high neckline and oversized sleeves. While the dramatic sleeves suit her, the artist gave Ariel’s look a modern twist. She swapped the sleeves for a short tank top. In addition, her voluminous hair reflects a style that’s currently back in vogue. However, the artist suggests that straight hair would offer a more contemporary feel, balancing her vintage-inspired dress with a fresh, updated hairstyle.

3. Tiana (The Princess and the Frog)

Tiana’s glow-up enhances her natural texture while adding volume and length. The result is a striking transformation.

4. Belle (Beauty and the Beast)

With its modest design, apron, and timeless hairstyle, Belle’s signature blue gown from Beauty and the Beast draws on traditional French fashion. The artist reimagined Belle with long, straight hair, imagining how she might look today, to bring her look into the present. Her outfit has also been modernized, with the apron removed in favor of a sleek, all-blue gown. This gives Belle a fresh, contemporary feel while retaining the core of her character’s original charm.

5. Moana (Moana)

Moana has been given a stunning makeover that enhances her natural beauty. The artist kept her gorgeous texture intact but styled it with trendy braids. The braids accentuate her vibrant personality. To add depth to her look, a thoughtful arm tattoo reflects her deep connection to her heritage and culture, adding charm and meaning to her updated look.

6. Eric (The Little Mermaid)

With a sleek and stylish update, Eric’s glow-up brings the character into the modern era. The Prince now wears a sharply tailored suit with a contemporary cut. His tie adds a sophisticated touch. This refined look gives Eric a polished, modern edge while maintaining his classic charm. It transforms him into a character who fits seamlessly into today’s world while still embodying the elegance of royalty.

7. Cinderella (Cinderella)

Cinderella’s signature soft, wavy hairstyle has been reimagined for her modern glow-up. The artist opted for sleek, straight hair to give her a fresh, contemporary vibe. In addition to this updated look, she now wears a pair of earrings in each ear, adding a stylish and on-trend detail that places her firmly in today’s fashion scene. These subtle changes refresh her classic look and bring her in line with today’s trends, while still honoring her timeless elegance.

8. Elsa (Frozen II)

Elsa’s look in Frozen II already has a modern feel to it. However, the artist has given her a fresh update with a new hairstyle. Elsa’s glow-up features a trendy buzz cut, giving her a sleek and contemporary look.

9. Mulan (Mulan)

Mulan’s outfits have always been a source of admiration, but the artist has given her a bold, fresh twist that completely transforms her look. This modern update features an eye-catching tattoo on her sleeve that adds a fierce and edgy vibe to her character. To give Mulan a more dramatic and commanding presence, the artist has also lengthened her hair.

10. Rapunzel (Tangled)

Tangled is set in the 1780s. Rapunzel’s dress, with its puffed shoulders and corset, hints at the style of the period, but the design isn’t entirely accurate. The artist gave her a modern twist by updating her hairstyle and adding subtle details to her shoulders. This allowed her to show more skin than was customary at the time. This imaginative reworking blends historical elements with a contemporary flair. The result is a look that feels visually striking and loosely tied to the past.

11. Meg (Hercules)

Meg’s transformation is nothing short of stunning. The artist has given her a bold, modern makeover by emphasizing her eyes with a dramatic smokey eye look. This makeup style adds depth and intensity to her gaze, making her eyes the focal point of her face. Complementing the smokey eyes are thicker, more defined lashes that further enhance her striking features. This combination of smokey eyes and lush lashes not only modernizes Meg’s appearance but also accentuates her confident and fierce personality, bringing her character into the contemporary era with a fresh and captivating look.

12. Anna (Frozen II)

Frozen II is Set in the 1840-1850’s. Anna’s style is heavily inspired by traditional Norwegian folk clothing, which is evident in her clothing design. While beautifully crafted, the artist has modernized Anna’s appearance with a playful braid and trendy choker. These subtle updates add a fun, contemporary twist to her character, seamlessly blending her historical roots with a fresh look that resonates with today’s fashion trends.

13. Snow White (Snow White and the Seven Dwarfs)

Snow White’s puffed sleeves are a reference to 16th-century fashion. Her standing white collar is believed to be an homage to a standing partlet that was seen in Italian artwork of the time. In her modern update, these intricate details have been streamlined, the result being a charming blue dress that has a fresh, contemporary look. In addition, Snow White’s hairstyle has been updated to reflect a more contemporary style. This enhances her overall image while still honoring her classic character.

14. Aurora (Sleeping Beauty)

Aurora’s peasant dress is a fascinating blend of different eras, rather than belonging to a single time period. For example, her contrasting collar is reminiscent of women’s fashion from the 1940s and 50s, adding a touch of vintage charm. However, the artist has modernized her look by giving the princess a Barbie-like makeover, transforming her into a character that bears a striking resemblance to the iconic doll.

Bonus: Mulan

Mulan’s transformation into a modern bride is a breathtaking blend of tradition and contemporary elegance. The artist has reimagined her wedding look with a sleek and sophisticated gown that seamlessly combines classic elements with modern design. The gown features clean lines and a minimalist aesthetic, highlighting Mulan’s natural grace and strength. Her hairstyle has been updated to a chic updo, adding a touch of sophistication and refinement. The addition of subtle yet meaningful accessories completes her transformation, making Mulan a stunning and timeless bride who embodies both her cultural heritage and contemporary style.

As we marvel at these modern transformations, you might be surprised to learn that some Disney characters were inspired by real people. Stay tuned for our next article, where we reveal 10 Disney characters you didn’t know were based on real people.

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A Father Unleashes “Superdad Powers” to Stop a Flying Baseball Bat From Hitting the Son’s Head

A Father Unleashes “Superdad Powers” to Stop a Flying Baseball Bat From Hitting the Son’s Head

A Father Unleashes “Superdad Powers” to Stop a Flying Baseball Bat From Hitting the Son’s Head

Parenting often reveals hidden superpowers, ones you didn’t even know you possessed until the moment demands their use. Shaun Cunningham’s heroic display of “Dad-mode” during a baseball game is a testament to this phenomenon.

Eight-year-old Landon, eagerly watching his favorite team, was taking photos with his camera when an unexpected rogue baseball bat hurtled dangerously toward him in the stands.

His father, Shaun, recounted, “I didn’t have a lot of time to think. Once I realized it was headed for my son, I just did anything I could to block it and deflect it.”

What’s truly remarkable is the visible contrast: Landon’s father fearlessly moved towards it as others in the crowd scrambled to evade the incoming danger. This moment encapsulates the essence of fatherhood — a poignant image of unwavering paternal protection that has touched hearts across the internet since it unfolded in 2016.

For a long time to come, Landon will have more than just a baseball game to boast about to his friends.

Landon summed it up, saying, “My first baseball game was amazing.’’

While sweet stories about moms abound, let’s not forget about the dads. Luckily for us, there are tons of stories similar to Shaun and Landon’s. To celebrate the greatness of fathers, we’ve gathered some sweet and humorous tales about the remarkable men who proudly bear this title.

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Light-Speed AI: MIT’s Ultrafast Photonic Processor Delivers Extreme Efficiency

Light-Speed AI: MIT’s Ultrafast Photonic Processor Delivers Extreme Efficiency

Fully Integrated Deep Neural Network Photonic Processor
Researchers demonstrated a fully integrated photonic processor that can perform all key computations of a deep neural network optically on the chip, which could enable faster and more energy-efficient deep learning for computationally demanding applications like lidar or high-speed telecommunications. Credit: Sampson Wilcox, Research Laboratory of Electronics.

A new photonic chip designed by MIT scientists performs all deep neural network computations optically, achieving tasks in under a nanosecond with over 92% accuracy.

This could revolutionize high-demand computing applications, opening the door to high-speed processors that can learn in real-time.

Photonic Machine Learning

Deep neural networks, the driving force behind today’s most advanced machine-learning applications, have become so large and complex that they are pushing the limits of traditional electronic computing hardware.

Photonic hardware, which uses light instead of electricity to perform machine-learning calculations, offers a faster, more energy-efficient solution. However, certain neural network operations have been difficult to achieve with photonic devices, forcing reliance on external electronics that slow down processing and reduce efficiency.

Breakthrough in Photonic Chip Technology

After a decade of research, scientists from MIT and collaborating institutions have developed a breakthrough photonic chip that overcomes these challenges. They demonstrated a fully integrated photonic processor capable of performing all essential deep neural network computations entirely with light, eliminating the need for external processing.

The optical device was able to complete the key computations for a machine-learning classification task in less than half a nanosecond while achieving more than 92 percent accuracy — performance that is on par with traditional hardware.

Photonic Neural Networks and Their Implications

The chip, composed of interconnected modules that form an optical neural network, is fabricated using commercial foundry processes, which could enable the scaling of the technology and its integration into electronics.

In the long run, the photonic processor could lead to faster and more energy-efficient deep learning for computationally demanding applications like lidar, scientific research in astronomy and particle physics, or high-speed telecommunications.

Research Team and Future Prospects

“There are a lot of cases where how well the model performs isn’t the only thing that matters, but also how fast you can get an answer. Now that we have an end-to-end system that can run a neural network in optics, at a nanosecond time scale, we can start thinking at a higher level about applications and algorithms,” says Saumil Bandyopadhyay ’17, MEng ’18, PhD ’23, a visiting scientist in the Quantum Photonics and AI Group within the Research Laboratory of Electronics (RLE) and a postdoc at NTT Research, Inc., who is the lead author of a paper on the new chip.

Bandyopadhyay is joined on the paper by Alexander Sludds ’18, MEng ’19, PhD ’23; Nicholas Harris PhD ’17; Darius Bunandar PhD ’19; Stefan Krastanov, a former RLE research scientist who is now an assistant professor at the University of Massachusetts at Amherst; Ryan Hamerly, a visiting scientist at RLE and senior scientist at NTT Research; Matthew Streshinsky, a former silicon photonics lead at Nokia who is now co-founder and CEO of Enosemi; Michael Hochberg, president of Periplous, LLC; and Dirk Englund, a professor in the Department of Electrical Engineering and Computer Science, principal investigator of the Quantum Photonics and Artificial Intelligence Group and of RLE, and senior author of the paper. The research was published on December 2 in Nature Photonics.

Machine Learning with Light

Deep neural networks are composed of many interconnected layers of nodes, or neurons, that operate on input data to produce an output. One key operation in a deep neural network involves the use of linear algebra to perform matrix multiplication, which transforms data as it is passed from layer to layer.

But in addition to these linear operations, deep neural networks perform nonlinear operations that help the model learn more intricate patterns. Nonlinear operations, like activation functions, give deep neural networks the power to solve complex problems.

In 2017, Englund’s group, along with researchers in the lab of Marin Soljacic, the Cecil and Ida Green Professor of Physics, demonstrated an optical neural network on a single photonic chip that could perform matrix multiplication with light.

But at the time, the device couldn’t perform nonlinear operations on the chip. Optical data had to be converted into electrical signals and sent to a digital processor to perform nonlinear operations.

“Nonlinearity in optics is quite challenging because photons don’t interact with each other very easily. That makes it very power consuming to trigger optical nonlinearities, so it becomes challenging to build a system that can do it in a scalable way,” Bandyopadhyay explains.

They overcame that challenge by designing devices called nonlinear optical function units (NOFUs), which combine electronics and optics to implement nonlinear operations on the chip.

The researchers built an optical deep neural network on a photonic chip using three layers of devices that perform linear and nonlinear operations.

A Fully-Integrated Network

At the outset, their system encodes the parameters of a deep neural network into light. Then, an array of programmable beamsplitters, which was demonstrated in the 2017 paper, performs matrix multiplication on those inputs.

The data then pass to programmable NOFUs, which implement nonlinear functions by siphoning off a small amount of light to photodiodes that convert optical signals to electric current. This process, which eliminates the need for an external amplifier, consumes very little energy.

“We stay in the optical domain the whole time, until the end when we want to read out the answer. This enables us to achieve ultra-low latency,” Bandyopadhyay says.

Achieving such low latency enabled them to efficiently train a deep neural network on the chip, a process known as in situ training that typically consumes a huge amount of energy in digital hardware.

“This is especially useful for systems where you are doing in-domain processing of optical signals, like navigation or telecommunications, but also in systems that you want to learn in real time,” he says.

The photonic system achieved more than 96 percent accuracy during training tests and more than 92 percent accuracy during inference, which is comparable to traditional hardware. In addition, the chip performs key computations in less than half a nanosecond.

“This work demonstrates that computing — at its essence, the mapping of inputs to outputs — can be compiled onto new architectures of linear and nonlinear physics that enable a fundamentally different scaling law of computation versus effort needed,” says Englund.

The entire circuit was fabricated using the same infrastructure and foundry processes that produce CMOS computer chips. This could enable the chip to be manufactured at scale, using tried-and-true techniques that introduce very little error into the fabrication process.

Scaling up their device and integrating it with real-world electronics like cameras or telecommunications systems will be a major focus of future work, Bandyopadhyay says. In addition, the researchers want to explore algorithms that can leverage the advantages of optics to train systems faster and with better energy efficiency.

Reference: “Single-chip photonic deep neural network with forward-only training” by Saumil Bandyopadhyay, Alexander Sludds, Stefan Krastanov, Ryan Hamerly, Nicholas Harris, Darius Bunandar, Matthew Streshinsky, Michael Hochberg and Dirk Englund, 2 December 2024, Nature Photonics.
DOI: 10.1038/s41566-024-01567-z

This research was funded, in part, by the U.S. National Science Foundation, the U.S. Air Force Office of Scientific Research, and NTT Research.

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Stanford Experts Sound Alarm on “Remarkably Harmful Toxin”

Stanford Experts Sound Alarm on “Remarkably Harmful Toxin”

Rusty Pipes
A new U.S. plan to remove lead pipes underscores lead’s persistent risks, with researchers calling for global measures to reduce exposure, especially in vulnerable communities.

The U.S. aims to replace lead pipes to combat ongoing exposure risks. Researchers stress urgent action on policies and alternatives to curb global lead contamination.

The Biden administration’s recently announced plan to replace all lead pipes in the U.S. is a reminder that the toxic metal remains a threat, even in a country that has largely banned its use. The smallest levels of lead exposure can cause a range of health damages over time, especially to children’s brain development.

Stanford researchers Stephen Luby and Jenna Forsyth have spent years examining the widespread presence of lead in low-income countries, including in some commonly consumed products. They led a perspective published Nov. 5 in The Lancet Public Health that tallies lead’s global health and economic costs, and a study in the November issue of Science of the Total Environment that highlights the urgent challenge of lead contamination in South Asian turmeric.

Lead is a remarkably harmful toxin,” said Luby. “Even within the context of limited resources, we have to find ways to focus on reducing exposure to it.”

Below, Luby, the Lucy Becker Professor of Medicine in the Stanford School of Medicine, and Forsyth, a research scientist with the School of Medicine, discuss the prevalence of lead-tainted products, and share insights on how food safety policies, education, and lead-free alternatives could reduce the risks.

You call for a complete phase-out of lead by 2035. What do you see as the key hurdles to achieving this goal, especially in countries with limited regulatory enforcement?

Luby: The key hurdles include overcoming the pushback from industries that, like tobacco companies, have a financial incentive in continuing to generate a product that kills millions of people every year. This requires a clear-eyed view of the enormous human and environmental health costs of having lead in the economy.

Dust Collection Bangladesh
A researcher collects dust in a home in Mymensingh, Bangladesh, for lead analysis. Credit: Musa Baker

When we consider the great success of removing chlorofluorocarbons from the atmosphere, the technological innovations in aerosol propellants and in refrigerants occurred in high-income countries within companies that understood that regulation was on the horizon. By the time the Montréal protocol came into force, low-income countries could purchase new-generation propellants in refrigerants that were affordable and did not exert such damage to the Earth’s protective ozone layer.

Lead contamination disproportionately affects marginalized communities. What policy interventions or public health measures could ensure that these vulnerable populations are protected?

Luby: Globally, industrial pollution is disproportionately discharged near communities with limited economic and political influence. Efforts to reduce industrial discharges are important, but because lead is so toxic to the environment and human life, the primary public health measure should be to remove it from the economy. This way, the whole web of life, including humans, would benefit.

Forsyth: And since lead does not degrade or go away on its own, remediation of current contaminated sites is a companion endeavor to reduce exposure among the most vulnerable.

Lead chromate in turmeric is a form of food fraud that can have devastating long-term effects. What immediate steps can governments and international organizations take to halt this practice, and how can consumer awareness be raised?

Forsyth: Our experience in Bangladesh suggests that three immediate actions would halt the practice. First is to improve awareness about lead’s toxicity. Second is to enhance detection. Often, food safety officers have too many priorities, too little bandwidth, and limited-to-no testing capacity. Finally, enforcing food safety policy is essential: fining sellers of tainted turmeric. Even just enforcing food safety policy once can have a sustained effect.

Turmeric Roots Polished With and Without Lead Chromate
Turmeric roots polished with and without lead chromate in Pabna Bangladesh. Credit: Sukhita Karthikeyakannan

In your research on lead-acid batteries, you highlight their significant contribution to global lead use. What alternative technologies hold the most promise for replacing lead-acid batteries, and how can these solutions be made accessible to developing nations?

Luby: Currently, lithium-ion batteries are lighter, last longer, and have a lower total cost of ownership than lead acid batteries. They are well placed to immediately replace lead acid batteries in nearly all applications. The best step that low-income countries can take is to remove tariffs on importing lithium-ion batteries so that they can compete against highly polluting lead acid battery industries.

Forsyth: It is likely that improved awareness and financing, such as microfinance loans, will be needed to overcome higher upfront cost of alternatives to lead acid batteries. Because of the broadening electrification of the global energy grid, there is enormous investment in battery technology. In the coming decades, there will be multiple alternatives including sodium-ion, magnesium-iron, and aluminum-iron technologies.

Additional Info

Research by Luby and Forsyth, initially funded by the Stanford Woods Institute for the Environment and the Stanford King Center on Global Development, identified lead adulteration in turmeric as the primary cause of elevated blood lead levels across rural Bangladesh. Since then, their collaboration with government authorities has led to the implementation of stricter testing and quality control measures in the spice industry, enhancing food safety protocols. Public health initiatives and education campaigns informed by the project have targeted interventions to reduce lead exposure in affected populations and inform people about the risks of lead contamination in spices.

The project’s geographical scope has expanded to India and Pakistan, where similar contamination issues have been identified, and its focus has expanded to investigate and address pollution from the lead-acid battery industry. Now called Project Unleaded, the initiative is part of the Stanford Center for Human and Planetary Health. It aims to identify and prioritize the most important sources of lead poisoning globally, investigate health impacts, advance rapid lead detection techniques, and develop, test, and scale up interventions to eliminate major sources of lead contamination.

References: “Removing lead from the global economy” by Stephen P Luby, Jenna E Forsyth, Zafar Fatmi, Mahbubur Rahman, Jesmin Sultana, Erica L Plambeck, N Grant Miller, Eran Bendavid, Peter J Winch, Howard Hu, Bruce Lanphear and Philip J Landrigan, 5 November 2024, The Lancet Planetary Health.
DOI: 10.1016/S2542-5196(24)00244-4

“Evidence of turmeric adulteration with lead chromate across South Asia” by Jenna E. Forsyth, Dinsha Mistree, Emily Nash, Manyu Angrish and Stephen P. Luby, 23 July 2024, Science of The Total Environment.
DOI: 10.1016/j.scitotenv.2024.175003

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Tomato Genetics: A Unexpected Journey Into a “Parallel Universe”

Tomato Genetics: A Unexpected Journey Into a “Parallel Universe”

Tomato Plant Genetics Art
Researchers at Michigan State University found that tomato plants utilize two separate metabolic pathways to produce acylsugars in roots and trichomes, offering new strategies for natural pest resistance in agriculture. Credit: SciTechDaily.com
In a new study recently published by Science Advances, Michigan State University researchers reveal an unexpected genetic revelation about the sugars found in “tomato tar,” shedding light on plant defense mechanisms and their potential applications in pest control.

Tomato tar, a familiar nuisance of avid gardeners, is the sticky, gold-black substance that clings to hands after touching the plant. It turns out that the characteristic stickiness of the substance serves an important purpose. It’s made of a type of sugar called acylsugar that acts as a natural flypaper for would-be pests. “Plants have evolved to make so many amazing poisons and other biologically active compounds,” said Michigan State researcher Robert Last, leader of the study. The Last lab specializes in acylsugars and the tiny, hair-like structures where they’re produced and stored, known as trichomes.

In a surprising discovery, researchers have found acylsugars, once thought to be found exclusively in trichomes, in tomato roots as well. This finding is a genetic enigma that raises as many questions as it does insights.

The objective of the MSU study was to learn about the origins and function of these root acylsugars. They found that not only do tomato plants synthesize chemically unique acylsugars in their roots and trichomes, but these acylsugars are produced through two parallel metabolic pathways. This is the equivalent of assembly lines in an auto factory making two different models of the same car, but never interacting.

MSU Tomato Seedlings
In Michigan State’s Department of Biochemistry and Molecular Biology, tomato seedlings are grown for the Last lab’s research into the Solanaceae plant family, also known as nightshades. The researchers analyzed unique chemical differences between roots and shoots, both of which contained acylsugars. Credit: Connor Yeck/MSU
These findings are helping scientists gain a better understanding of the resilience and evolutionary story of Solanaceae, or nightshades, a sprawling family of plants that includes tomatoes, eggplants, potatoes, peppers, tobacco, and petunias.

They could also provide valuable information for researchers looking to develop molecules made by plants into compounds to help humanity. “From pharmaceuticals, to pesticides, to sunscreens, many small molecules that humans have adapted for different uses come from the arms race between plants, microbes, and insects,” Last said.

Roots and Shoots

Beyond key chemicals essential for growth, plants also produce a treasure trove of compounds that play a crucial role in environmental interactions. These can attract useful pollinators and are the first line of defense against harmful organisms.

“What’s so remarkable about these specialized metabolites is that they’re typically synthesized in highly precise cells and tissues,” said Rachel Kerwin, a postdoctoral researcher at MSU and first author of the latest paper.

“Take for instance acylsugars. You won’t find them produced in the leaves or stems of a tomato plant. These physically sticky defense metabolites are made right in the tip of the trichomes.”

When it was reported that acylsugars could be found in tomato roots as well, Kerwin took it as a call for old-fashioned genetic detective work.

Jaynee Hart, Rachel Kerwin and Robert Last
From left to right: Jaynee Hart, Rachel Kerwin and Robert Last pose in front of analytical equipment at Michigan State University’s Mass Spectrometry and Metabolomics Core. The team of researchers unraveled an evolutionary and genetic mystery in tomato plants. Credit: Connor Yeck/MSU

“The presence of these acylsugars in roots was fascinating and led to so many questions. How did this happen, how are they being made and are they different from the trichome acylsugars we’ve been studying?”

To begin tackling the evolutionary enigma, lab members collaborated with specialists at MSU’s Mass Spectrometry and Metabolomics Core and staff at the Max T. Rogers Nuclear Magnetic Resonance facility.

In comparing metabolites from tomato seedlings’ roots and shoots, a variety of differences appeared. The basic chemical makeup of the aboveground and belowground acylsugars were noticeably different, so much so that they could be defined as different classes of acylsugars entirely.

Breaking the Car

Last, a University Distinguished Professor in MSU’s College of Natural Science’s Department of Biochemistry and Molecular Biology and Department of Plant Biology, offers a useful analogy to explain how a geneticist approaches biology. “Imagine trying to figure out how a car works by breaking one component at a time,” he said. “If you flatten a car’s tires and notice the engine still runs, you’ve discovered a critical fact even if you don’t know what the tires exactly do.”

Switch out car parts for genes, and you get a clearer picture of the work accomplished by the Last lab to further crack the code on root acylsugars.

Looking at public genetic sequence data, Kerwin noticed that many of the genes expressed in tomato trichome acylsugar production had close relatives in roots. After identifying an enzyme believed to be the first step in root acylsugar biosynthesis, the researchers began “breaking the car.”

When they knocked out the root acylsugar candidate gene, root acylsugar production vanished, leaving trichome acylsugar production untouched.

Meanwhile, when the well-studied trichome acylsugar gene was knocked out, root acylsugar production carried on as usual.

These findings offered striking proof of a suspected metabolic mirroring.

“Alongside the aboveground acylsugar pathway we’ve been studying for years, here we find this second parallel universe that exists underground,” Last said.

“This confirmed we have two pathways co-existing in the same plant,” Kerwin added.

To drive home this breakthrough, Jaynee Hart, a postdoctoral researcher and second author on the latest paper, looked closer at the functions of trichome and root enzymes.

Just as trichome enzymes and the acylsugars they produce are a well-studied chemical match, she found a promising link between root enzymes and the root acylsugars as well.

“Studying isolated enzymes is a powerful tool for ascertaining their activity and drawing conclusions about their functional role inside the plant cell,” Hart explained.

These findings were further proof of the parallel metabolic pathways that exist in a single tomato plant.

“Plants and cars are so different, yet similar in that when you open the proverbial hood you become aware of the multitude of parts and connections that make them function. This work gives us new knowledge about one of those parts in tomato plants and prompts further research into its evolution and function and whether we can make use of it in other ways,” said Pankaj Jaiswal, a program director at the U.S. National Science Foundation, which funded the work.

“The more we learn about living things — from tomatoes and other crops to animals and microbes — the broader the opportunities to employ that learning to benefit society,” he added.

Clusters Within Clusters

The paper also reports a fascinating and unexpected twist concerned with biosynthetic gene clusters, or BGCs.

BGCs are collections of genes that are physically grouped on the chromosome and contribute to a particular metabolic pathway. Previously, the Last lab identified a BGC containing genes linked to trichome acylsugars in tomato plants. Kerwin, Hart, and their collaborators have now discovered the root-expressed acylsugar enzyme resides in the same cluster.

“Usually in BGCs, the genes are co-expressed in the same tissues and under similar conditions,” said Kerwin.“But here, we have two separate yet interlinked groups of genes. Some expressed in trichomes, and some expressed in roots.”

This revelation led Kerwin to dive into the evolutionary trajectory of Solanaceae species, with hopes of identifying when and how these two unique acylsugar pathways developed. Specifically, the researchers drew attention to a moment some 19 million years ago when the enzyme responsible for trichome acylsugars was duplicated. This enzyme would one day be responsible for the newly discovered root-expressed acylsugar pathway.

The exact mechanism that “switched on” this enzyme in roots remains unknown, paving the way for the Last lab to continue to unpack the evolutionary and metabolic secrets of the nightshade family.

“Working with Solanaceae provides so many scientific resources, as well as a strong community of researchers,” said Kerwin.

“Through their importance as crops and in horticulture, these are plants humans have cared about for thousands of years.”

For Last, these breakthroughs are also a reminder of the importance of natural pesticides, which defense metabolites such as acylsugars ultimately represent.

“If we find that these root acylsugars are effective at repelling harmful organisms, could they be bred into other nightshades, thereby helping plants grow without the need for harmful synthetic fungicides and pesticides?” Last asked.

“These are questions at the core of humanity’s pursuit of purer water, safer food and a reduced reliance on harmful synthetic chemicals.”

Reference: “Tomato root specialized metabolites evolved through gene duplication and regulatory divergence within a biosynthetic gene cluster” by Rachel E. Kerwin, Jaynee E. Hart, Paul D. Fiesel, Yann-Ru Lou, Pengxiang Fan, A. Daniel Jones and Robert L. Last, 24 April 2024, Science Advances.
DOI: 10.1126/sciadv.adn3991

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Sunflower Secrets Unveiled: Multiple Origins of Flower Symmetry Discovered

Sunflower Secrets Unveiled: Multiple Origins of Flower Symmetry Discovered

Sunflower Family Tree
A new sunflower family tree reveals that flower symmetry evolved multiple times independently. Species of the sunflower family with or without bilateral flower symmetry. Chrysanthemum lavandulifolium (upper left) and Artemisia annua (upper right) are closely related species from the same tribe; the former has bilaterally symmetric flowers (the rays) and the latter does not. Rudbeckia hirta (lower left) from the sunflower tribe has bilaterally symmetric flowers, and Eupatorium chinense (lower right) from the Eupatorieae tribe does not; these two tribes are closely related groups. A sunflower (center) shows flowers with bilateral symmetry (the large petal-like flowers in the outer row) and without (the small flowers in the inner rows). Credit: Guojin Zhang, Ma laboratory, Penn State

The sunflower family tree revealed that flower symmetry evolved multiple times independently, a process called convergent evolution, among the members of this large plant family, according to a new analysis. The research team, led by a Penn State biologist, resolved more of the finer branches of the family tree, providing insight into how the sunflower family — which includes asters, daisies, and food crops like lettuce and artichoke — evolved.

A paper describing the analysis and findings, which researchers said may help identify useful traits to selectively breed plants with more desirable characteristics, appeared online in the journal Plant Communication.

“Convergent evolution describes the independent evolution of what appears to be the same trait in different species, like wings in birds and bats,” said Hong Ma, Huck Chair in Plant Reproductive Development and Evolution, professor of biology in the Eberly College of Science at Penn State and the leader of the research team. “This can make it difficult to determine how closely related two species are by comparing their traits, so having a detailed family tree based on DNA sequence is crucial to understanding how and when these traits evolved.”

Advances in Sunflower Family Genealogy

The sunflower head, for example, is actually a composite composed of multiple much smaller flowers. While the head is generally radially symmetric — it can be divided into two equal halves in multiple directions like a starfish or a pie — the individual flowers can have different forms of symmetry. According to the new study, bilateral symmetry — where there is only one line that divides the flower into two equal halves — has evolved and been lost multiple times independently in sunflowers over evolutionary history. The researchers found that this convergent evolution is likely related to changes in the number of copies and the expression patterns of the floral regulatory gene, CYC2.

In recent years, many family trees for a group of related species have been built by extensively using transcriptomes, which are the genetic sequences of essentially all of the genes expressed by a species, the researchers explained. Transcriptomes are easier to acquire than high-quality whole-genome sequences for a species but are still difficult and costly to prepare and require fresh plant samples. To increase the number of species available for comparison the team turned to low-coverage genome sequences, which are produced through a process called genome skimming and are relatively inexpensive and easy to prepare, even from dried plant samples.

“To get an accurate whole-genome sequence for a species, each letter of its DNA alphabet must be read — or covered — multiple times to minimize errors,” Ma said. “For the purposes of building a family tree, we show in this paper that we can get away with lower coverage genome sequences. This allowed us to increase the number of species in our analysis, which, in turn, allowed us to resolve more of the finer branches on the sunflower family tree.”

The team used a combination of publicly available and newly generated transcriptomes, along with a large number of newly obtained skimmed genomes, for a total of 706 species with representatives from 16 subfamilies, 41 tribes, and 144 subtribe-level groups in the sunflower family. The subfamilies are major subdivisions of the family, while the tribes and subtribe can contain one or more of genera, which is the classification level just above the species.

“Previous versions of the sunflower family tree had established the relationships among most of the subfamilies and many tribes, which are equivalent to the main branches of a tree,” Ma said. “With our increased sample size, we were able to resolve more of the smaller branches and twigs at the subtribe and genus level. This higher-resolution tree allowed us to reconstruct where and when traits like flower symmetry evolved, demonstrating that bilateral symmetry must have evolved many times independently.”

Molecular Insights and Future Directions

The team also studied the molecular evolution of genes involved in flower development among sunflowers. They found that one of these genes, CYC2, which is found in multiple copies in the genomes of each species, was activated in species with bilaterally symmetric flowers, suggesting that it might be part of the molecular basis for the convergent evolution of this trait. To further test this, the team performed experiments to quantify CYC2 gene expression in the flowers of species with different types of symmetry.

“Our analysis showed a clear relationship between CYC2 expression and flower symmetry, suggesting that changes in how these genes are used in various sunflower species is likely involved in the convergent evolution observed in the family,” Ma said. “The sunflower family is one of the two largest families of flowering plants containing over 28,000 species, including many economically important agricultural and horticultural species. Understanding how these species are related to one another allows us to determine how and when their traits evolved. This knowledge could also be used to identify useful traits that could be bred into domesticated species from closely related wild ones.”

Reference: “Nuclear phylogenomics of Asteraceae with increased sampling provides new insights into convergent morphological and molecular evolution” by Guojin Zhang, Junbo Yang, Caifei Zhang, Bohan Jiao, Jose L. Panero, Jie Cai, Zhi-Rong Zhang, Lian-Ming Gao, Tiangang Gao and Hong Ma, 25 February 2024, Plant Communications.
DOI: 10.1016/j.xplc.2024.100851

In addition to Ma, the research team includes Guojin Zhang at Penn State; Junbo Yang, Jie Cai, Zhi-Rong Zhang, and Lian-Ming Gao at the Kunming Institute of Botany in Kunming, China; Caifei Zhang at the Wuhan Botanical Garden and Sino-Africa Joint Research Centre in Wuhan, China; Bohan Jiao and Tiangang Gao at the State Key Laboratory of Plant Diversity and Specialty Crops in Beijing, China; and Jose L. Panero at the University of Texas, Austin.

Funding from the Eberly College of Science and the Huck Institutes of the Life Sciences at Penn State, the Strategic Priority Research Program of the Chinese Academy of Sciences, the Large-scale Scientific Facilities of the Chinese Academy of Sciences, and the National Natural Science Foundation of China supported this research.

Sunflower Secrets Unveiled: Multiple Origins of Flower Symmetry Discovered Read More